Burke Pharmaceutical

CURRICULUM VITAE FOR MICHAEL ALISTAIR FRAISE, MD

Office Address:
301 W. St. Louis St.
Hot Springs, AR 71913-4457

LICENSURE
Arkansas, #C-8188
New York, #194485
Kansas, #04-24565
Manitoba, #13-218
United Kingdom. #1741726
Radioactive Material License / ARK-390-BP497 authorized user

CERTIFICATION
1974 - Educational Commission for Foreign Medical Graduates (7-24-74)
1977 - Membership of the Royal Colleges of Physicians of the United Kingdom
1978 - Visa Qualifying Examination (VQE) - (9/7/78)
1984 - Fellow Royal College of Physicians (Cardiology) - (12/3/84)
1988 - Fellow of American College of Cardiology - (8/22/88)
1990 - Federation Licensing Examination (FLEX) - (12/90)

PROFESSIONAL SOCIETIES
American College of Cardiology, Fellows 8/22/88
Royal College of Physicians of Canada. Fellow, 12/3/84
Royal College of Physicians of the United Kingdom, Member

HONORS AND AWARDS
1970 - 1971: Liverpool University Rugby League Club Treasurer Colours, 1971
1982: Alberta Cardiovascular Society Resident Competition

PAST APPOINTMENTS
01/86 - 10/87Pfizer Central Research, Clinical Project Manager, Sandwich, Kent, England
10/87 - 06/91St. Boniface General Hospital, Assistant Professor of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
07/91 - 12193 University of Arkansas, Associate Professor of Medicine, Little Rock, Arkansas
01/94 - 06/95 AlbanyAssociates in Cardiology, 2 Palisades Drive, Executive Woods Albany, NY 12205
07/95 - 10/97 Suto Cardiology, P. 0. Box 1527, 1660 West “C” Place, Russellville, AR 72811

EDUCATION
Liverpool College
Liverpool, England 1959-68
(College Scholarship, 1964)

Liverpool University Medical School
Liverpool, England
M.B., ChB, 1969-1974
MD (Doctoral Thesis) 1981

POST GRADUATE TRAINING
09/1974 - 02/1975
House Officer, General Medicine
Broadgreen Hospital, Liverpool, England
(Drs. G.E. Honey and B.A. Walker)

03/1975 - 08/1975
House Officer, General Surgery
Broadgreen Hospital, Liverpool, England
(Mr. M.J. Moroney)

09/1975 - 08/1976
Senior House Officer, Cardiology
Regional Cardiac Centre, Sefton General Hospital
Liverpool, England
(Drs. C. McKendrick., N. Coulshed, E. Epstein, and A. Harley)

09/1976 - 08/1977
Senior 1-louse Officer, General Medicine,
Professorial Unit
Broadgreen Hospital, Liverpool, England
(Drs. TJ Bayley, GE Honey and BA Wa1.k~r)

10/1977 - 09/1978
Registrar, General Medicine, Professorial Unit
Liverpool Royal Infirmary, Liverpool, England
(Prof. DA Price Evans and Dr. CC Evans)

10/1978 - 06/1979
Registrar, General Medicine
Walton Hospital, Liverpool, England
(Dr. MB McCauley)

07/1979 - 09/1979
Research Fellow in Cardiology
CVRI Moffitt Hospital
University of California, San Francisco, CA
(Prof. MM Scheinman)

10/1979 - 06/1980
Research Fellow in Cardiology
VA Medical Center, Valley Medical Center
Fresno, California
(Prof. IA Abbott and Dr. L Grayson)

07/1980 - 06/1981
Research Fellow in Cardiology
CVRI, Moffitt Hospital
University of California, San Francisco, CA
(Dr. ER Botvinick)

07/1981- 06/1982
Resident in Cardiology
Foothills Hospital, University of Calgary
Calgary, Alberta, Canada
(Dr. ER Smith)

07/1982 - 06/1983
Fellow/Honorary Resident in Cardiology
Alberta Heritage Foundation for Medical Research
Foothills Hospital, University of Calgary
Calgary, Alberta, Canada
(Dr. ER Smith and Prof. JV Tyberg)

02/1982 – 12/1985
Research Fellow in Cardiology
Honorary Registrar in Cardiology
Dept. of Cardiovascular Studies
Department of Medical Cardiology Leeds General Infirmary, Leeds,
England (Dr. SH Taylor)

PUBLICATIONS
1. Russell NH, Keenan JP, Frais MA. Thrombocytopathy associated with autoimmune haemolytic anaemia. Brit Med J 2:604, 1978.
2. Frais MA. Gastric a4enocarcinoma due to ataxia-telangiectasia (Louis-Bar syndrome). J Med Genetics 16:160-161, 1979.
3. Frais MA, Bayley TJ. Left ventricular failure with labetalol. Postgrad Med J 55:567-568,
1979.
4. Frais MA, Bayley TJ. Ocular reaction to timolol maleate. Postgrad Med J 55:884-885,
1979.
5. Carlsson B, Silverman NH, Botvinick E, Frais M. Cardiac imaging. Diag Imaging 2:10-
36, 1980.
6. Botvinick E, Dunn R, Frais M, O’Connell W, Shosa D, Herfkens R, Scheinman M. The phase Image: its relationship to patterns of contraction and conduction. Circulation 65:551-560, 1982.
7. Frais M, Botvinick E, Shosa D, O’Connell W. Are regions of ischaemia detected on stress perfusion scintigraphy predictive of sites of subsequent myocardial infarction? Brit Heart J 47:357-364, 1982.
8. Frais MA, Botvinick EH, Shosa DW, O’Connell JW, Scheinman MM, Hattner RS, Morady F. Phase image characterization of ventricular contraction in left and right bundle branch block. Am J Cardiol 50:95-105, 1982.
9. Botvinick EM. Frais MA, Shosa DW, O’Connell SW, Pacheco-Alvarez JA, Scheinman M, Hattner RS, Morady F., Faulkner DB. An accurate means of detecting and characterizing abnormal patterns of ventricular activation by phase image analysis. Am J Cardiol 50:289-298, 1982.
10. Misbacb GA, Botvinick EU, Tyberg IV, Parmley WW, Dunn RF, Frais M. The functional implications of scintigraphic measures of myocardial ischemia and infarction. Am Heart J 106:996-1002, 1983.
11. Frais MA, Manyari DE, Duff HJ, Wyse DO, White AVM, Mitchell LH. Coexistent arrhyythmogenic right ventricular dysplasia and Wolff-Parkinson-White syndrome. Am J Cardiol 53:632-634, 1984.
12. Nimrod CA, Beresford P. Frais M Belenkie I, Tyberg JV, Fremit A, Smith E. Hemodynamic observations on pulmonary edema associated with a beta-mimetic agent: a report of two cases. J Reprod Med 29:341-344, 1984.
13. Botvinick E, Frais M, O’Connell W, Faulkner D, Scheinman M, Morady F, Sung R, Shosa D, Dae
M. Phase image evaluation of patients with ventricular pre-excitation syndromes. J Am Coll Cardiol 3:799-814, 1984.
14. Frais MA, Silke B, Fitness to fly: detection of coronary artery disease in asymptomatic pilots. Brit J Aviation Med 2:24-30, 1984.
15. Jackson NC, Silke B, Verma SP. Reynolds G, Frais MA., Hafizullah M, Taylor SH. Haemodynamic effects of nicardipine during upright exercise in patients with stable angina pectoris. Postgrad Med J 60(Suppl 4):11-16, 1984.
16. Silke B, Verma SP, Hafizullah M, Reynolds G, Frais MA. Jackson NC, Taylor SH. Haemodynamic effects of micardipine in acute myocardial infarction. Postgrad Med J 60(Suppl 4):29-34, 1984.
17. Frais M, Botvinick E, Shosa D, O’Connell W, Pacheco-Alvarez J, Dae M, Hattner R, Faulkner D. Phase image characterization of localized and generalized left ventricular contraction abnormalities. J Am Coll Cardiol 4:987-998, 1984.
18. Smiseth OA, Frais MA, Kingma I, Smith ER, Tyberg JV. Assessment of pericardial constraint in dogs. Circulation 71:158-164, 1985.
19. Smiseth OA, Frais MA, Refsum H, Smith ER, Tyberg JV. The pericardial hypothesis: a mechanism of acute shifts of the left ventricular diastolic pressure-vo1ume relation. Clin Physiol 5:403-415, 1985.
20. Frais MA, Silke B, Ahuja RC, Verma SP, Nelson GIC, Taylor SH Cardioselective beta-blockade with atenolol and acebutolol following acute myocardial infarction: a multiple dose haemodynamic comparison. J. Cardiovasc Pharmacol 7:80-85. 1985.
21. Jackson N, Verma SF. Frais, MA, Silke B, Hafizullah M, Reynolds CI, Taylor SM. Haemodynamic dose-response effects of flecainide acetate in acute myocardial infarction with and without left ventricular decompensation. Clin Pharmacol Therap 37:619-624, 1985.
22. Taylor SH, Frais M, Lee P, Verma SP, Jackson N, SiIke B. Antihypertensive dose-response effects of nicardipine in stable essential hypertension. Brit J Clin Pharmacol 20(Suppl 1):135S-138S, 1985.
23. Taylor SH, Frais MA, Lee P, Verma SP, Jackson N, Reynolds G. Silke B. A study of the long-term efficacy and tolerability of oral nicardipine in hypertensive patients. Brit J Clin Pharmacol 20(Suppl L):139S-142S, 1985.
24. Silke B, Verma SP, Frais MA, Hafizullah M, Taylor SH. Effects of nicardipine on cardiac volume at rest and during exercise-induced angina. Brit J Clin Pharmacol 20(Suppl 1):169S-176S, 1985.
25. Silke B, Verma SP, Nelson GIC, Hussain M, Forsyth D, Frais MA, Taylor SH The effects on left ventricular performance of verapamil and metoprolol singly and together in exercise-induced angina pectoris. Am Heart J 109:1286-1293, 1985.
26. Silke B, Verma SP, Frais MA, Reynolds G, Jackson N, Taylor SH. Haemodynamic analysis of the effects of nicardipine arid metoprolol alone and in combination in coronary artery disease. Eur Heart J 6:930-938, 1985.
27. Silke B, Verma SF, Frais MA, Hafizullah M, Taylor SH. Effects of buccal nitrate on left ventricular haemodynamics and volume at rest and during exercise-induced angina. Brit J Clin Pharmacol 20:437-446, 1985.
28. Silke B, Fiais MA, Muller P, Verma SP, Reynolds G, Taylor SH. Haemodynamic dose-response effects of intravenous nisoldipine in coronary attely disease. Brit J Clin Pharmacol 20:675-680. 1985.
29. Silke B, Frais MA, Verma SP, Reynolds G, Taylor SH Differences in haemodynamic response to beta-blocking drugs between stable coronary artery disease and acute myocardial infarction. Euro J Clin Pharmacol 29:659-665, 1986.
30. Silke B, Verma SP, Reynolds G, Frais MA, Taylor SH Haemodynamic effects of beta¬-adrenergic blocking drugs in acute myocardial infarction. Revista Latina de Cardiologia 1986.
31. Silke B, Graham DJM. Verma SP, Reynolds G, Frais MA, Findlayson JR, Taylor SH.
Pharmacokinetic and radinuclide studies with nicardipine in coronary artery disease. Eur J Clin Pharmacol 29:651-657, 1986.
32. Silke B, Verma SP, Frais MA, Reynolds G. Taylor SH. Comparative effects of metoprolol and celiprolol on cardiac haemodynamics and left ventricular volume at rest and during exercise-induced angina. Clin Pharmacol Therap 39:5-14, 1986.
33. Silke B, Verma SP, Frais MA, Reynolds G, Taylor SH. Differential actions of atenolol and celiprolol on cardiac performance in ischemic heart disease. J Cardiovasc Pbarmacol (Suppl 4)8:S138-S144, 1986.
34. Silke B, Verma SP, Frais MA, Reynolds G, Taylor SH. A rest and exercise haemodynamic evaluation of a new cardioselective beta-adrenoceptor blocker celiprolol alone and in combination with nitroglycerine in ischemic heart disease. Brit J Clin Pharmacol 22:697-706, 1986.
35. Smiseth OA, Frais MA, Kingma I, White AV, Knudtson ML, Cohen JM. Manyari DE,
Smith ER, Tyberg JV. Assessment of pericardial constraint the relation of right
ventricular filling pressure and pericardial pressure measured after pericardiocentesis. J
Am Coll Cardiol 7:307-314, 1986.
36. Manyari DE, Frais MA, Smith ER. Nuclear cardiology techniques in the assessment of ischemic heart disease. Chin Invest Med 9:76-93, 1986.
37. Frais MA, Silke B, Verma SP, Sharma S. Reynolds G, Jackson N, Taylor SH. A
haemodynamic dose finding study with a. new slow calcium channel blocker (amlodipine)
in coronary artery disease. Herz 11:351-358, 1986.
38. Silke B, Frais MA, Verma SP, Reynolds GW, Hafizullah M, Kalra PA, Jackson NC, Taylor SH. Comparative haemodynamic effects of intravenous lignocaine, disopyramide and flecainide in uncomplicated acute myocardial infarction. Brit J Clin Pharmacol 22:707-714, 1986.
39. Silke B, Nelson GIC, Verma SP, Frais MA, Reynolds G, Jackson N, Taylor SH. Haemodynamic dose-response effects of intravenous indoramin in acute heart failure complicating myocardial infarction, J Cardiovasc Pharmacol 8(Suppl 4):S102-S106, 1986.
40. Silke B, Frais MA, Verma SP, Reynolds G, Taylor SH, Jackson NC. A review of the haemodynamic effects of nicardipine in ischemic heart disease. Brit J Clin Pharmacol
22(Supp1 3):203S-213S, 1986.
41. Silke B, Verma SP, Midtbo KA, Muller P, Frais MA, Reynolds G, Taylor SM. A haemodynamic study of the effects of combined slow-calcium channel blockade (metoprolol) and beta-blockade (rnetoprolol) in coronary heart disease. Int’l J Cardial 13:231-241, 1986.
42. Silke B, Frais MA, Midtbo KA, Verma SP, Sharma S, Reynolds G, Jackson N, Taylor SH, Comparative haemodynamic effects of five slow calcium channel-blocking agents in coronary artery disease. Clin Pharmacol Therap 42:381-387, 1987.
43. Verma SP, Silke B, Reynolds G, Muller P, Frais MA, Taylor SH. Immediate effects of bumetanide on systemic haemodynamics and left ven~icu1ar volume in acute and chronic heart failure. Brit J Clin Pharmacol 24:21-32, 1987.
44. Kingma I, Smiseth OA, Frais MA, Smith ER. Tyberg JV. Left ventricular external constraint - Relationship between pericardial, pleural and esophageal pressures during positive end-expiratory pressure and volume loading in dogs. Ann Biomed Eng 15:331-346, 1987.
45. Silke B, Verma SP, Shanna SK, Baig W, Jackson NC, Reynolds G, Frais MA, Taylor SH. Haemodynamic dose-response actions of cicloprolol in left ventricular dysfunction due to ischemic heart disease. Int’l J Cardiol 17:127-136, 1987.
46. Jackson NC, Taylor SH. Frais MA. Hemodynamic comparison of dopexamine hydrochloride and dopamine in ischemic left ventricular dysfunction. Am J Cardiol 62:73C-77C, 1988.
47. Silke B, Verma SP, Sharma SK, Frais MA, Reynolds G, Taylor SH. Comparative effects of atenolol and cicloprolol on cardiac performance in coronary heart disease. S Cardiovasc Pharmacol 13:155-161, 1989.
48. Hanly PJ, Millar TW, Steljes DG, Baert R, Frais MA, Kryger MH. Respiration and abnormal sleep in patients with congestive heart failure. Chest 96:480-488, 1989.
49. Hanly PJ, Millar TW, Steljes DG, Baert R, Frais MA, Kryger MH. Effect of oxygen ott respiration and sleep in patients with congestive heart failure. Ann Int Med 111:777-782, 1989.
50. Frais MA, Bergman DW, Kingma I, Smiseth OA, Smith ER, Tyberg JV. The dependence of the time consent of left ventricular isovolumic contraction CD on pericardial pressure. Circulation 81:1071-1080 1990.
51. Frais MA, Hoeschen RJ. Exercise-induced T wave normalization is not specific far myocardial ischemia detected by perfusion scintigraphy. Am Heart J 119:1225-1229, 1990.
52. Frais MA, Rodgers K. Dramatic electrocardiographic T wave changes associated with gastric dilatation. Chest 98:489-490, 1990.
53. Millar TW, Hanly PJ, Hunt B, Frais MA, Kryger MH{The entrainment of low frequency breathing periodicity. Chest 98:1143-1148, 1990.
54. Smiseth OA, Frais MA, Junemann M, Kingma I, Refsum H, Smith ER, Lipton MJ, Tyberg JV. Left and right ventricular diastolic function during acute pericardial tamponade. Clin Physiol 11:61-71, 1991.
55. Thomson IR, Bowering JB, Hudson RJ, Frais MA, Rosenbloom M. A comparison of desflurane and isoflurane in patients undergoing coronary artery surgery. Anesthesiology 75:776-781, 1991.
56. Frais MA, Dowie A, McEwen B, Wyeth B, Kim SW. The response of the QT-sensing rate-adaptive ventricular pacemaker to mental stress. Am Heart J 126:1219-1222, 1993.

ABSTRACTS AND COMMUNICATIONS.
1. Peters R, Abbott I, Desai J, Frais MA, Scheinman M. Natural history of bundle branch block, effects of prophylactic pacemaker insertion. Proc Europ Cong Cardiol, Paris, France, June 22-26, p.225, 1980.
2. Herfkens RJ, Hattner RS, Botvinick EH, Shosa DW, O’Connell JW. Herfkens PG. Frais MA, Engelstad B. Use of rotating slant hole tomography in the eva1ution of pyrophosphate infaret imaging. Proc Radiol Soc of North America, Dallas, Texas, p.192, 1980.
3. Frais MA, Botvinick EH.. Is stress perfusion scintigraphy predictive of sites of subsequent myocardial infarction? Clin Res 29:77A. 1981.
4. Frais MA, Botvinick EM, Parmley WW. Is stress perfusion scintigraphy predictive of sites of subsequent myocardial infarction? Clin Res 29:192A, 1981.
5. Williams J, Frais M Angina pectoris precipitated by unheated water mattresses. New Engl J Med 304:909-910, 1981 (letter).
6. Frais MA, Botvinick EH, O’Connell JW, Sbosa DW, Scheinman MM, Hattner RS. The phase image: an accurate means of detecting and localizing abnormal foci of ventricular activation. J Nucl Med 22:P18, 1981.
7. Shosa DW, O’Connell JW, Botvinick EH, Frais MA, Hattner RS. Analysis of ventricular contraction abnormalities in amplitude/phase space - the st